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探讨CD44V6表达与胃癌发生发展的关系。方法:采用免疫组化染色方法,检测20例正常胃粘膜上皮、43例异型增生和85例胃癌组织CD44V6的表达情况。结果:正常胃粘膜无CD44V6表达;异型增生CD44V6的阳性表达率为30.2％(13/43),CD44V6表达阳性率与异型增生严重程度密切相关(P<0.05);胃癌组织阳性率为74.1％(63/85),其表达阳性率和染色强度均显著高于异型增生(P<0.05),CD44V6表达强度与胃癌浸润深度(P<0.05)、淋巴结转移(P<0.01)、肿瘤生长方式(P<0.05)、静脉和淋巴管侵袭(P<0.05)及远处转移(P<0.05)密切相关,且Ⅰ、Ⅱ期胃癌CD44V6染色强度和阳性率均显著低于Ⅲ、Ⅳ期(P<0.05)。结论:CD44V6上调表达与胃癌的发生发展密切相关,并发生于癌变的早期阶段,检测CD44V6表达有助于胃癌的早期诊断和转移潜能的评估。
To investigate the relationship between the expression of CD44V6 and the occurrence and development of gastric cancer. Methods: Immunohistochemical staining was used to detect the expression of CD44V6 in 20 cases of normal gastric epithelium, 43 cases of dysplasia and 85 cases of gastric cancer. Results: There was no expression of CD44V6 in normal gastric mucosa. The positive rate of CD44V6 was 30.2% (13/43). The positive rate of CD44V6 expression was closely related to the severity of dysplasia (P<0.05). The positive rate of gastric cancer tissue was 74.1% ( 63/85), the expression positive rate and staining intensity were significantly higher than those of dysplasia (P<0.05), the intensity of CD44V6 expression and depth of invasion of gastric cancer (P<0.05), lymph node metastasis (P<0.01), tumor growth patterns (P <0.05), venous and lymphatic invasion (P<0.05) and distant metastasis (P<0.05) were closely related, and the staining intensity and positive rate of CD44V6 in stage I and II gastric cancer were significantly lower than those in stage III and IV (P<0.05). ). Conclusion: Up-regulation of CD44V6 expression is closely related to the occurrence and development of gastric cancer, and occurs in the early stage of canceration. Detection of CD44V6 expression is helpful for the early diagnosis of gastric cancer and the evaluation of metastatic potential.