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目的研究提前注射绒促性素(hCG)的促排卵方案,即限制性促排卵(LOS)方案,在预防卵巢过度刺激综合征(OHSS)发生中的作用。方法对10例OHSS高危的不孕患者,其中8例为多囊卵巢综合征(PCOS)患者,采用促性腺激素释放激素激动剂(GnRHa)长方案超排卵,当最大卵泡直径达到12·0~14·5mm时注射hCG10000U,36h后取卵,行常规体外受精或单精子卵母细胞质内注射及胚胎移植。结果10例患者均无OHSS发生,获卵11~35个,其中成熟卵4~28个,均在取卵周期行胚胎移植。胚胎移植后妊娠8例,其中输卵管妊娠1例。结论LOS方案可以使PCOS不孕患者在获得足够多的成熟卵、有效防止OHSS发生的同时不降低妊娠率。
Objective To investigate the effect of ovulation induction (LOS) regimen in preventing ovarian hyperstimulation syndrome (OHSS) by injecting cashmere feline hormone (hCG) in advance. Methods 10 cases of infertile women with high risk of OHSS were enrolled. Eight of them were patients with polycystic ovary syndrome (PCOS). The patients were ovariectomized with the long protocol of gonadotropin-releasing hormone agonist (GnRHa). When the maximum follicle diameter reached 12.0 ~ 14.5 mm hCG10000U injection, 36h after ovulation, routine in vitro fertilization or intracytoplasmic sperm injection and embryo transfer. Results None of the 10 patients had OHSS and 11 to 35 eggs were obtained, of which 4 to 28 were mature eggs, all of which were embryo transferred in the oocyte retrieval cycle. Eight cases of pregnancy after embryo transfer, including tubal pregnancy in 1 case. Conclusions The LOS regimen can make enough mature eggs for patients with PCOS infertility and effectively prevent the occurrence of OHSS without reducing the pregnancy rate.