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本文报告了关于广岛原爆存活者骨髓细胞(105例)和外周血 T 淋巴细胞(39例)、B 淋巴细胞(4例)的细胞遗传学变化以及发生慢性粒细胞白血病和乳癌的两例病人定期检查的细胞遗传学结果。骨髓细胞染色体畸变分析表明,距离下爆心0.5km 以内和0.5—1 km 的受照者分别有90%和52.4%出现染色体畸变,染色体畸变细胞分别占观察细胞总数的23.2%和12.8%,每一组都有7例出现异常克隆(Clone)。出现的畸变类型大多数是稳定型的,非稳定型的极少见。在 T淋巴细胞染色体畸变分析方面,不同距离的两组出现的稳定型畸变(19.6%,22.1%)或非稳定型畸变(2.0%,2.2%)的发生率几乎一致。592个异常中期细胞断裂点的位置呈现规律性的趋向,存活者也出现 B 淋巴细胞的染色体畸变,33—50%的细胞系为异常核型,结果提示某些异常核型的 B 淋巴细胞在体内正在形成一种克隆。由这些细胞遗传学表现可以认为,从接受照射到白血病发生,似乎包含着染色体质变与量变的许多阶段。
This article reports on the cytogenetic changes of bone marrow cells (105 cases) and peripheral blood T lymphocytes (39 cases) and B lymphocytes (4 cases) in Hiroshima primary survivors and two cases of chronic myeloid leukemia and breast cancer Check the cytogenetic results. Chromosome aberration analysis of bone marrow cells showed that chromosome aberrations occurred in 90% and 52.4% of the irradiated subjects within 0.5km and 0.5-1km, respectively, with chromosome aberrations accounting for 23.2% and 12.8% of the total observed cells, respectively There were 7 cases of clones in the group. Most of the types of distortion that occur are stable, and non-stable ones are rare. In the analysis of chromosomal aberrations in T lymphocytes, stable distortions (19.6%, 22.1%) or unstable aberrations (2.0%, 2.2%) were almost identical in two groups at different distances. The locations of 592 abnormal metaphase cell breakpoints tended to be regular. Chromosome aberrations of B lymphocytes also appeared in survivors, and abnormal karyotypes in 33-50% of the cell lines. The results suggested that some of the abnormal karyotype B lymphocytes A clone is forming in the body. From these cytogenetic manifestations, it appears that there are many stages of chromosomal alterations and quantification from exposure to leukemia.