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用兔抗人C-erbB-2抗体对133例人胃癌组织进行了免疫组织化学研究,其中24例呈阳性反应(18.1%).结果显示:C-erbB-2表达阳性者有较好的生物学特性.C-erbB-2基因的过度表达是胃癌恶性程度较低的一个指标,术前组织活检测定C-erbB-2的表达情况,有助于判断胃癌的恶性程度,制订手术切除和淋巴结清扫范围.对86例胃癌患者进行了术后5年随访,统计后发现C-erbB—2阳性的病例比阴性病例有较低的近期死亡率和较高的5年生存率,但无显著性差异(P>0.05).C-erbB-2表达与胃癌预后的关系,有待于在更大的病组中作进一步研究.
The rabbit anti-human C-erbB-2 antibody was used to perform immunohistochemical studies on 133 cases of human gastric cancer tissues, of which 24 cases were positive (18.1%). The results showed that: C-erbB-2 positive expression has better biological Characteristics: Over-expression of C-erbB-2 gene is an indicator of low degree of malignancy of gastric cancer. Preoperative tissue biopsy to determine the expression of C-erbB-2 is helpful to determine the degree of malignancy of gastric cancer, and to develop surgical resection and lymph nodes. Clearing range. Eighty-six patients with gastric cancer were followed up for 5 years. After the statistics, it was found that C-erbB-2-positive cases had lower recent mortality and higher 5-year survival rate than negative cases, but there was no significant difference. Difference (P>0.05). The relationship between C-erbB-2 expression and the prognosis of gastric cancer remains to be further studied in the larger disease group.