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为探讨血清白介素-10(IL-10)在儿童支气管肺炎中的临床意义,我们采用ELISA法检测49例支气管肺炎以及21例健康对照组小儿的血清IL-10。结果支气管肺炎组血清IL-10较健康对照组显著增高(P<0.01),支气管肺炎中外周血WBC≥10.0×10~9/L组、CRP阳性组的血清IL-10较WBC<10.0×10~9/L组、CRP阴性组显著增高(P均<0.01);血清IL-10≥1000pg/ml组住院天数、肺部罗音吸收天数较IL-10<1000pg/ml组显著增高(P均<0.01)。故血清IL-10变化可望作为判断支气管肺炎病情及转归的估计指标之一。
To investigate the clinical significance of serum interleukin-10 (IL-10) in children with bronchopneumonia, we used ELISA to detect IL-10 in 49 children with bronchopneumonia and 21 healthy controls. Results Serum IL-10 in bronchopneumonia group was significantly higher than that in healthy control group (P <0.01). The levels of IL-10 in peripheral blood of bronchopneumonia with WBC≥10.0 × 10 ~ 9 / L and CRP positive group were significantly higher than those with WBC <10.0 × 10 (P <0.01). The days of hospitalization with IL-10≥1000 pg / ml in serum and the days of pulmonary rales absorption were significantly higher than those in IL-10 <1000pg / ml group (P < <0.01). Therefore, changes in serum IL-10 is expected to be as one of the indicators to determine the prognosis of bronchial pneumonia and outcome.