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目的:研究Lewis y抗原及整合素α5、β1在卵巢浆液性肿瘤中的表达及其意义。方法:应用免疫组织化学方法检测30例卵巢浆液性囊腺癌、11例交界性卵巢浆液性囊腺瘤、13例卵巢浆液性囊腺瘤、11例正常卵巢组织中Lewis y抗原及整合素α5、β1的表达情况。结果:Lewis y抗原在卵巢浆液性囊腺癌中的阳性表达率为90.0%,明显高于交界性(63.6%)、良性卵巢浆液性囊腺瘤(38.5%)及正常卵巢组织(0)中的表达(P均<0.05)。整合素α5、β1在卵巢浆液性囊腺癌中的阳性表达率分别为86.7%和83.3%,高于两者在交界性(72.7%,72.7%)、良性卵巢浆液性囊腺瘤(69.2%,53.8%)及正常卵巢组织(36.4%,36.4%)中的表达(P均<0.05)。Lewis y抗原及整合素α5、β1在卵巢浆液性囊腺癌中的表达呈显著正相关(P均<0.01)。结论:Lewis y抗原及整合素α5、β1在卵巢浆液性囊腺癌中的阳性表达率普遍增高,且两者的表达呈显著性正相关。提示Lewis y抗原及整合素α5、β1在卵巢浆液性囊腺癌的发生、发展中起着重要作用。
Objective: To study the expression of Lewis y antigen and integrin α5, β1 in ovarian serous tumors and its significance. Methods: The expressions of Lewis y antigen and integrin α5 in 30 cases of ovarian serous cystadenocarcinoma, 11 cases of borderline ovarian serous cystadenoma, 13 cases of ovarian serous cystadenoma and 11 cases of normal ovarian tissue were detected by immunohistochemistry. , Β1 expression. Results: The positive rate of Lewis y antigen in ovarian serous cystadenocarcinoma was 90.0%, which was significantly higher than that in borderline (63.6%), benign ovarian serous cystadenoma (38.5%) and normal ovarian tissue (0) (All P <0.05). The positive rates of integrin α5 and β1 in ovarian serous cystadenocarcinoma were 86.7% and 83.3% respectively, which were higher than those in the borderline (72.7%, 72.7%) and benign ovarian serous cystadenoma (69.2% , 53.8%) and normal ovarian tissue (36.4%, 36.4%) (P all <0.05). Lewis y antigen and integrin α5, β1 in ovarian serous cystadenocarcinoma was positively correlated (P <0.01). Conclusion: The positive expression rates of Lewis y antigen and integrin α5 and β1 in ovarian serous cystadenocarcinoma are generally higher than those in normal ovarian serous cystadenocarcinoma. It is suggested that Lewis y antigen and integrin α5, β1 play an important role in the occurrence and development of ovarian serous cystadenocarcinoma.