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目的探讨纤维支气管镜导管介入对耐多药肺结核的治疗价值。方法经纤维支气管镜导管介入空洞病灶内注入氧氟沙星及丁胺卡那霉素加化疗治疗耐多药肺结核４８例，与单纯化疗４０例进行对照研究。结果经纤维支气管镜导管介入治疗组疗程结束时痰菌阴转率９２％，病灶显效率９６％，空洞闭合率２７％，均显著高于单纯化疗组的６３％、５８％及１０％（Ｐ＜０．０１～０．０５）。结论经纤维支气管镜导管介入空洞病灶内注药加化疗治疗耐多药肺结核，疗效显著优于单纯化疗，且无并发症及明显毒副反应。
Objective To investigate the therapeutic value of bronchoscopic catheterization for multi-drug resistant pulmonary tuberculosis. Methods Forty-eight patients with multidrug-resistant pulmonary tuberculosis were treated with ofloxacin and amikacin plus chemotherapy in patients with intravitreous injection of fibrobronchial tubes, and 40 patients were treated with chemotherapy alone. Results The rate of sputum negative conversion was 92%, the effective rate of lesions was 96%, the void closure rate was 27% at the end of the treatment with bronchoscopic catheterization group, which were significantly higher than 63%, 58% and 10% of the chemotherapy alone group (P <0.01 ~ 0.05). Conclusion Intravenous injection of fibrobronchial catheters into cavitary lesions and chemotherapy for multidrug-resistant pulmonary tuberculosis have a significantly better curative effect than chemotherapy, and no complications and obvious side effects.