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β-内酰胺抗生素是青霉素类(图1-1)和头孢菌素类(图1-2)抗生素的总称。这类抗生素由于它们具有优良的抗菌力和选择毒性而广泛应用于临床。但由于对这类抗生素的耐药菌的普遍出现和弱毒菌的分离频度的增加等原因,当前如何解决上述问题以保留这类抗生素的优点就显得十分重要和迫切。
Beta-lactam antibiotics are generic names for penicillins (Figure 1-1) and cephalosporins (Figure 1-2). These antibiotics are widely used clinically due to their excellent antibacterial and selective toxicity. However, due to the prevalence of antibiotic-resistant bacteria and the increasing frequency of separation of attenuated bacteria, it is very important and urgent to solve the above problems in order to preserve the advantages of such antibiotics.