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目的:观察尿激酶(UK)对实验小鼠短暂性脑供血不全样发作(TIA)有无预防作用。方法:本实验利用过氧化物(t-BHP+H_2O_2)尾静脉注射及缺氧致小鼠产生TIA样发作为实验动物模型,观察尾静脉注射尿激酶的作用。结果:尿激酶可以降低小鼠的症状出现率(对照组出现率96.88％,尿激酶组为59.26％,P<0.05)及症状学评分(P<0.05),降低小鼠病死率(观察的前2天病死率对照组为44.11％,尿激酶组为20.00％,P<0.05;前3天病死率对照组为55.88％,尿激酶组为20.00％,P>0.05;前4天病死率对照组为61.76％,尿激酶组为36.37％,P>0.05),延长症状出现时间(P<0.05)。结论:尿激酶在预防脑内微血栓形成的实验小鼠TIA样发作中有确切的效果。
Objective: To investigate whether urokinase (UK) has preventive effect on transient ischemic attack (TIA) in experimental mice. Methods: In this experiment, TIA-like hair samples were generated from tail vein injection and hypoxia of t-BHP + H_2O_2 mice as experimental animal model to observe the effect of injecting urokinase into tail vein. Results: Urokinase could reduce the incidence of symptoms in mice (96.88% in control group, 59.26% in urokinase group, P <0.05) and symptomology score (P <0.05) The 2-day mortality rate was 44.11% in the control group and 20.00% in the urokinase group, P <0.05; the mortality rate in the first 3 days was 55.88% in the control group and 20.00% in the urokinase group, P> 0.05; (61.76%) and urokinase group (36.37%, P> 0.05), prolonging the appearance of symptoms (P <0.05). Conclusion: Urokinase has an exact effect in preventing TIA-like episodes in experimental mice with intracerebral microthrombosis.