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目的研究双环醇片治疗慢性乙型肝炎的临床疗效。方法选择121例慢性乙型肝炎病人随机分2组接受治疗,试验组61例,每日服用双环醇片75mg;对照组60例,给予每日口服复方甘草酸苷150mg。2组均连续用药12周。观察治疗前后血清氨基转移酶水平的改变。结果2组血清氨基转移酶均得到明显下降,试验组更为显著(P<0.05,P<0.01)。2组均未发生严重不良事件。结论双环醇片治疗慢性乙型肝炎在生物化学方面取得较好疗效且安全。
Objective To study the clinical efficacy of bicyclol tablets in the treatment of chronic hepatitis B Methods A total of 121 patients with chronic hepatitis B were randomly divided into two groups. The experiment group consisted of 61 patients taking bicyclol tablets 75 mg daily and the control group 60 patients receiving daily oral compound glycyrrhizin 150 mg. The two groups were treated for 12 weeks. Changes in serum aminotransferase levels were observed before and after treatment. Results Serum aminotransferase in both groups were significantly decreased, the experimental group was more significant (P <0.05, P <0.01). No serious adverse events occurred in both groups. Conclusion Bicyclometacin in the treatment of chronic hepatitis B has a good biochemical efficacy and safety.