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目的:研究蔓生百部炮制前后止咳作用及其毒性差异。方法:采用小鼠氨水引咳法,对蔓生百部生品及蜜炙品水煎液、总生物碱部位的止咳作用进行比较;采用小鼠急性毒性实验,对生、炙蔓生百部水煎液、总生物碱及非碱部位进行毒性比较。结果:生品水煎液及非碱液给药后动物出现抽搐、进食不佳等中毒现象。生品总生物碱给药后动物表现出异常兴奋、互相撕咬等中毒现象。但蜜炙后水煎液、非碱液抽搐现象很弱,且很快恢复正常。蜜炙后总生物碱给药后兴奋度很低,且较快恢复正常。蜜炙百部水煎液及总生物碱止咳效果均强于生品。结论:蜜炙蔓生百部可达到增效减毒的作用。
Objective: To study the antitussive effects and the differences of their toxicity before and after processing of 100 parts of vine. Methods: Using the method of cough-inducing by ammonia in mice, comparing the antitussive action of decoction and alkaloid in the decoction of 100 parts of vine and honeysuckle, using the mice acute toxicity test, Liquid, total alkaloids and non-alkaline sites for toxicity comparison. Results: After the decoction of raw water and non-alkali solution, the animals experienced convulsions, poor eating and other poisoning phenomena. Total alkaloids after administration of raw animals showed abnormal excitement, biting each other poisoning phenomenon. However, honey after Sunburn decoction, non-alkali convulsions is very weak, and quickly returned to normal. Honeyburn total alkaloid excitability after administration is very low, and quickly returned to normal. Honey Sunburn one hundred decoction and total alkaloids cough better than raw products. Conclusions: Honey Sprouting 100 can achieve the effect of reducing toxicity.