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酮是一类重要的有机化合物,各种各样的合成方法被发展出来用于构建酮化合物.其中,过渡金属催化对氰基加成是构建酮化合物的一个重要的策略,但大多金属集中在前过渡金属.近年来,后过渡金属包括钯、铑、镍和铜等试剂催化的体系逐渐被发展出来,不仅官能化的底物被应用于该类反应,C-H活化和串联反应的策略也被应用于其中,拓展了这类反应.目前该领域已然成为了一个研究热点.本文主要根据金属插入和自由基两种不同类型的机理分类对该领域的研究进行综述.
Ketones are a kind of important organic compounds. A variety of synthetic methods have been developed for the construction of ketone compounds. Among them, the transition metal-catalyzed addition of cyanogens is an important strategy for building ketone compounds. However, most of the metal is concentrated in Former transition metals In recent years, more and more systems have been developed for the post-transitional metal catalysts, including palladium, rhodium, nickel and copper. Not only functionalized substrates have been applied to this type of reaction, but the strategies of CH activation and in-line reaction have also been proposed Applied to them and expanded these kinds of reactions.At present, the field has become a hot research field.This paper mainly reviews the research in this field according to the different types of mechanism of metal insertion and free radical.