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目的观察国产非诺贝特治疗高脂血症的疗效。方法选择辖区居民高甘油三酯血症和混合型高脂血症患者,随机分为服用国产非诺贝特的治疗组和服用进口非诺贝特的对照组,均以200mg/d口服,治疗观察8周。实验室检查治疗前后的TC、TG、HDL-C、LDL-C等项血脂系列指标以及FPG、肝肾功能等生化指标。结果经过8周治疗后,治疗组中高甘油三酯血症病例TG、apoB100水平明显下降,HDL-C水平有所升高;混合型高脂血症病例TC、TG、LDL-C、ApoB100水平明显下降,均有统计学显著性差异P<0.05。和对照组治疗8周后的相关指标水平基本相同。结论国产非诺贝特治疗高甘油三酯血症和混合型高脂血症疗效可靠,安全性好。
Objective To observe the efficacy of domestic fenofibrate in the treatment of hyperlipidemia. Methods Select hypertensive patients with hypertriglyceridemia and mixed hyperlipidemia were randomly divided into treatment group taking domestic fenofibrate and control group taking fenofibrate. All were treated with 200mg / d oral treatment Observed for 8 weeks. Laboratory tests before and after treatment of TC, TG, HDL-C, LDL-C and other items of lipid indicators and FPG, liver and kidney function and other biochemical indicators. Results After 8 weeks of treatment, the levels of TG and apoB100 in hypertriglyceridemia group were significantly decreased and HDL-C level was increased in the treatment group. The levels of TC, TG, LDL-C and ApoB100 were significantly higher in the patients with mixed hyperlipidemia Decreased, there were statistically significant differences P <0.05. Compared with the control group after 8 weeks of treatment, the relevant indicators were basically the same. Conclusion Domestic fenofibrate treatment of hypertriglyceridemia and mixed hyperlipidemia with reliable and safe.