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目的 :探讨急性脑梗塞 (cerebralinfarction ,CI)病人血清免疫球蛋白 (immunoglobuin ,Ig)、补体C3 (Complement ,C3 )之间的关系。方法 :CI病人 5 6例 ,同期神经内科住院其他疾病 40例 ,于入院后第 1天和治疗后第 10天清晨取静脉血测定不同组别血清Ig及C3 值。结果 :CI患者血清IgG、IgA较对照组显著升高 ( P <0 0 1) ,C3 则较对照组显著降低 (P <0 0 1)。治疗前后IgG、IgA、C3 较对照组显著好转 (P <0 0 1)。结论 :CI与血清免疫球蛋白、补体C3 有关系 :IgG、IgA升高 ,C3 下降可能是脑梗塞发生的危险因素 ,也可能是缺血后自身免疫炎症反应所致的一个重要指标
Objective: To investigate the relationship between serum immunoglobin (Ig) and complement C3 (C3) in patients with cerebral infarction (CI). Methods: Fifty-six patients with CI were enrolled in this study. Forty patients with other in-hospital neurological diseases were enrolled in the same period. Serum Ig and C3 were measured in different groups on the first day after admission and on the tenth day after treatment. Results: Serum IgG and IgA in patients with CI were significantly higher than those in control group (P <0.01), while those in C3 group were significantly lower than those in control group (P <0.01). Before and after treatment, IgG, IgA, C3 significantly improved compared with the control group (P <0.01). Conclusion: CI is associated with serum immunoglobulin and complement C3: elevated IgG and IgA, decreased C3 may be risk factors for cerebral infarction, and may be an important indicator of autoimmune inflammation after ischemia