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环境化学物遗传毒性评价的总体策略仍是以体外试验为主,以有限的体内试验为补充。体外试验方法在未来的评价体系中仍占有相当重要的地位。目前欧洲为主的各国学者研究开发以有代谢能力的人肝肿瘤细胞系Hep G2为指示细胞的体微核和单细胞凝胶电泳等体外试验,在实际应用中已证明对提高短期体外评价的速度和有效性很有成效;毒理基因组的研究更为环境化学物遗传毒性体外评价体系提供了发展的方向,虽不能很快应用到实践中去,但已引起了广泛的关注。
The overall strategy for environmental chemicals genotoxicity assessment is still based on in vitro tests, supplemented by limited in vivo testing. In vitro test methods in the future evaluation system still occupies a very important position. At present, European-based scholars from various countries have developed and tested in vitro experiments on the human hepatoma cell line Hep G2, which is a metabolizable human body, for somatic cell micronuclei and single-cell gel electrophoresis. In practical applications, Speed and effectiveness are very effective. The study of toxicological genome provides the direction for the development of in vitro environmental toxicity assessment of environmental chemicals. Although it can not be quickly applied to practice, it has drawn wide attention.