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以青霉素衍生物化学转化法,合成了16个单环β-内酰胺新化合物。体外抑菌试验结果表明化合物1b 对表皮葡萄球菌26069的最低抑菌浓度为6.2μg/ml。
Sixteen monocyclic β-lactam novel compounds were synthesized by chemical conversion of penicillin derivatives. In vitro antibacterial test results show that the minimum inhibitory concentration of compound 1b on Staphylococcus epidermidis 26069 is 6.2μg / ml.