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糖尿病肾病首发临床征象为尿白蛋白排泄增加,长期应用抗高血压药物有效控制血压能保护肾功能。血管紧张素转换酶(ACE)抑制剂对减少尿蛋白,延缓糖尿病肾病进展有特别作用,但钙通道阻滞剂的效果则报道不一。为确定钙通道阻滞剂心痛定和 ACE 抑制剂 Lisinopril对尿白蛋白排泄的作用,作者对有明显肾脏病的Ⅰ型糖尿病(IDD)患者进行短期交叉研究。病人和方法研究对象为12例,男7例,女5例,IDD 患者,有白蛋白尿,轻至中度高血压,血肌酐<200μol/L。研究包括两次3周强化治疗期,每次治疗期前4周停用抗高血压药
Diabetic nephropathy first clinical signs of increased urinary albumin excretion, long-term use of antihypertensive drugs effective blood pressure control can protect renal function. Angiotensin converting enzyme (ACE) inhibitors play a special role in reducing urinary protein and retarding the progression of diabetic nephropathy, but the effects of calcium channel blockers are reported differently. To determine the role of calcium channel blocker nifedipine and ACE inhibitor Lisinopril in urinary albumin excretion, we conducted a short-term crossover study of patients with idiopathic diabetes mellitus (IDD). Patients and methods were studied in 12 cases, 7 males and 5 females, IDD patients with albuminuria, mild to moderate hypertension, serum creatinine <200μol / L. The study included two intensive 3-week treatment sessions with antihypertensive discontinuation 4 weeks prior to each treatment session