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本文应用组织学的方法,观察了吡喹酮引起的NIH小鼠体内细粒棘球蝴的变化。结果表明,在剂量为500mg/kg/d ,连续给药15及90天时,生发层变性及坏死的发生率依次分别为41.3％及36.5％和23.5％及70.7％,两组间坏死率的差别有高度显著性(P<0.001);原头节变性及死亡的发生率依次分别为37.9％及1O.3％和28.4%及65.4％,两组间死亡率的差别亦有高度显著性(P<0.001)。连续治疗30～90天,少数细粒棘球蚴的角质层出现不同程度的局部破裂及炎性细胞侵入,部分受损生发层的表面还有炎性细胞的粘附。
In this paper, histological methods were used to observe the changes of echinococcus granulosus in NIH mice induced by praziquantel. The results showed that the incidence of degeneration and necrosis of the germinal layer was 41.3% and 36.5% and 23.5% and 70.7% respectively at the dosage of 500mg / kg / d for 15 and 90 days. The difference of necrosis rate between the two groups (P <0.001). The incidences of degeneration and death of primordial nodules were 37.9% and 10.3%, respectively, and 28.4% and 65.4%, respectively. The differences in mortality between the two groups were also highly significant (P <0.001). Continuous treatment of 30 to 90 days, a small number of echinococcus granulosum stratum corneum appeared varying degrees of local rupture and inflammatory cell invasion, some of the damaged surface of the germinal layer of inflammatory cell adhesion.