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应用核酸印迹技术(Southern blot),对我国十四省市自治区的1455例来源宫颈癌、官颈不典型增生、宫颈湿疣和正常宫颈组织,进行人乳头瘤病毒(HPV)感染的型别检测,并分析了其型别地理分布特点。结果发现,815例宫颈癌组织 HPV 总检出率53.5%,其中 HPV16和58型检出率最高,分别是31.9%和7.6%,HPV6/11和18型的检出率为2.3%和1.0%。而在195例宫颈上皮不典型增生中,HPV 总检出率为25.1%,16/58型和6/11型的检出率分别为4.6%、15.9%。206例宫颈湿疣中,HPV 检出率40.8%,6/11型最高,达33.5%。239例正常宫颈组织中,仅检出1例 HPV16型,5例6/11型。提示:我国宫颈癌 HPV 感染以16、58型为主,18型少见。还发现,北方地区的宫颈癌组织中,HPV 感染以16型为主;南方省份长江中下游地区,HPV58 型检出率明显增高,几乎和 HPV16型持平;沿海地区不明的相关型呈上升趋势。提示我国宫颈癌 HPV 感染的型别,可能存在“移行”的地理分布特点。
The type of human papillomavirus (HPV) infection was detected in 1455 cases of cervical cancer, atypical dysplasia, cervical condyloma and normal cervical tissue from 14 provinces, autonomous regions and municipalities in China by Southern blotting. And analyzed its type and geographical distribution characteristics. The results showed that the total HPV positive rate was 53.5% in 815 cases of cervical cancer, of which HPV16 and 58 were the highest (31.9% and 7.6%, HPV6 / 11 and 18 were detected in 2.3% and 1.0%, respectively) . In 195 cases of atypical hyperplasia of cervical epithelium, the total detection rate of HPV was 25.1%. The positive rates of HPV16 / 58 and 6/11 were 4.6% and 15.9% respectively. 206 cases of cervical condyloma, HPV detection rate of 40.8%, 6/11 type the highest, up to 33.5%. In 239 cases of normal cervical tissue, only 1 HPV16 and 5 6/11 were detected. Tip: HPV infection of cervical cancer in our country mainly in 16,58 type 18 rare. Also found that in the northern region of the cervical cancer, HPV infection in the 16-based; the southern provinces of the Yangtze River, HPV58 detection rate was significantly increased, almost unchanged and HPV16 type; related to the coastal area is an upward trend. Prompted the type of cervical cancer HPV infection in our country, there may be “travel ” geographical distribution.