Exosome最早由Trams在正常细胞和肿瘤细胞培养上清液中被发现,后来在研究网织红细胞最后成熟为红细胞阶段发现也释放同样的小囊泡状结构,并命名为Exosome。但这一发现并没有引起人们的重视。直到1996年Raposo等[1]发现B细胞分泌的Exosome能诱导抗原特异性T淋巴细胞反应和Zitvog Exosome was first detected by Trams in normal cells and tumor cell culture supernatants. Later, it was found that the same vesicle structure was also found in the study of reticulocyte maturation into erythrocytes and named as Exosome. However, this finding did not attract people’s attention. Until 1996 Raposo et al [1] found that Exosome secreted by B cells can induce antigen-specific T lymphocyte reaction and Zitvog