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目的比较C反应蛋白(CRP)和血清降钙素原(PCT)在诊断、鉴别下呼吸道感染中的差异性。方法 76例下呼吸道感染患者作为观察组。经过痰病原体检测将观察组患者分为细菌感染组(46例)和非细菌感染组(30例)。同时选择本院健康体检门诊中健康受试者50例作为对照组。均检测CRP和PCT并进行比较。结果细菌感染组PCT值(3.58±1.12)μg/L,显著高于非细菌感染组和对照组,差异有统计学意义(P<0.05),且高于正常值。细菌感染组CRP值(24.19±7.21)mg/L,显著高于非细菌感染组和对照组,差异有统计学意义(P<0.05),但非细菌感染组CRP值与对照组比较差异无统计学意义(P>0.05)。PCT的特异度(90.0%)高于CRP(66.7%),差异有统计学意义(χ2=4.81,P<0.05)。结论 PCT和CRP对于诊断下呼吸道感染均有一定的临床意义,且PCT的鉴别诊断效率更高,具有更为广泛的临床应用价值。
Objective To compare the difference between C-reactive protein (CRP) and serum procalcitonin (PCT) in diagnosis and differential diagnosis of lower respiratory tract infection. Methods 76 patients with lower respiratory tract infection as the observation group. After the sputum pathogen detection, the observation group was divided into bacterial infection group (46 cases) and non-bacterial infection group (30 cases). At the same time, 50 healthy subjects in our health check-up clinic were selected as the control group. Both CRP and PCT were tested and compared. Results The PCT value of bacterial infection group (3.58 ± 1.12) μg / L was significantly higher than that of non-bacterial infection group and control group (P <0.05), and higher than the normal value. The CRP value of bacterial infection group was (24.19 ± 7.21) mg / L, which was significantly higher than that of non-bacterial infection group and control group (P <0.05), but there was no statistic difference between non-bacterial infection group and control group Significance (P> 0.05). The specificity of PCT (90.0%) was higher than CRP (66.7%), the difference was statistically significant (χ2 = 4.81, P <0.05). Conclusions Both PCT and CRP have some clinical significance for the diagnosis of lower respiratory tract infection, and the differential diagnosis of PCT is more efficient and has more extensive clinical value.