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聚肌胞是一种人工合成的双链RNA,具有诱导细胞产生干扰素,广谱抗病毒、抗肿瘤作用。临床上用于治疗带状疱疹、单纯疱疹、水痘、流行性腮炎等多种因病毒感染所引起的疾病。聚肌胞原料、聚肌胞注射液的生产在我厂已有近二十年的历史,直至今日仍是我厂的主要生产品种,聚肌胞原料平均年产量在40~50kg,聚肌胞注射液年产量在2000万支,为我厂创造了一定的经济效益。聚肌胞是由核苷二磷酸(IDP、CDP)在多核苷磷酸化酶(PNPase)催化下分别合成聚肌苷酸(Poly I)和聚胞苷酸(Poly C),再将两条多核苷酸链以I∶C碱基配对形成双链的Poly I∶C,其简要工艺过程表示如下:
Polymyosin is a kind of synthetic double-stranded RNA, which has the function of inducing cells to produce interferon, broad spectrum anti-virus and anti-tumor effect. Clinically for the treatment of shingles, herpes simplex, chicken pox, epidemic mumps and other viral infections caused by a variety of diseases. Polymyosin raw materials, polymyosine injection production in our plant has been nearly 20 years of history, until today is still my main production plant varieties, polygons average annual production of raw materials in 40 ~ 50kg, polyp Injection annual output of 20 million, for my plant to create a certain degree of economic benefits. Polyinosarcoma is composed of nucleoside diphosphate (IDP, CDP) in poly-nucleoside phosphorylase (PNPase) catalyzed synthesis of poly inosine (Poly I) and poly cytidine (Poly C), and then two multi-core The nucleotide sequence of I: C is paired to form double strand Poly I: C. The brief process is as follows: