糖类抗原125（CA125）被用于卵巢肿瘤患者的筛查，敏感性高。近年来，在急慢性心力衰竭、顽固性心力衰竭患者中，发现血清CA125浓度的变化与心功能状态呈正相关关系。随着一例房间隔缺损合并右心功能衰竭患者的血清CA125浓度，在房间隔缺损封堵术后发生显著下降的发现，越来越多的研究开始揭示CA125和肺疾病间的关系。 CA125的监测简单易行，可能成为继脑钠肽后另一项重要的生物标志物，应用于心肺功能异常的监测中。现对CA125与心肺功能间的关系做一简要综述。“,”Because of glycoprotein carbohydrate antigen 125(CA125) with high diagnostic sensitivity,it was used for screening ovarian tumor in female patients.In recent years,in the patients with acute and chronic heart failure, refractory heart failure, a positive correlation was found between the change of state of cardiac function and serum CA125 concentration.It was found that an atrial septal defect patient with right heart failure,after the atrial septal defect closure,his serum CA125 concentration declined significantly.Now,more and more researches focus on the relationship between serum CA125 concentration and lung disease.CA125 monitoring is simple, may become one clinical important biomark-er that can be applied to monitor the heart and lung dysfunction.This paper will make a brief review of the relationship between CA125 and heart and lung function.