目的艾贝宁(盐酸右美托咪定注射液),是新一代α2肾上腺素能受体激动剂,其通过高选择性激动α2肾上腺素能受体(α2∶α1=1620∶1),具有镇静、镇痛、抗交感而无呼吸抑制的作用,本文就其与安慰剂组相比,用于小儿扁桃体操、腺样体切除术中镇静镇痛抗焦虑进行对比,以观察临床效果。方法选择期全麻下行小儿扁桃体操、腺样体切除51例,ASAⅡ～Ⅲ级,年龄7～9岁,体重22～28 kg,并随机分为两组:艾贝宁组26例,安慰剂组25例。麻醉诱导气管插管前,一组外周静脉缓推艾贝宁0.5μg/kg(D组)(n=26),另一组外周静脉缓推盐水安慰剂(P组)(n=25)。60s注射完毕。分别持续记录术中患儿的呛咳次数,并记录患者的喉痉挛、支气管痉挛或氧和不足情况,气管插管前、中、后均记录患者血氧饱和度、心率、呼吸频率、收缩压和舒张压。还需记录麻醉苏醒时间。结果两组呛咳评分中位数分别为1(1～3)和2(1～4)(P<0.05)。但两组屏气或氧和不足发生率无差别。两组患者支气管镜操作时的心率、收缩压和舒张压有所上升(P<0.05),但艾贝宁组升高更不明显。两组患者麻醉苏醒时间基本相同。结论本研究发现单次静脉注射艾贝宁可减轻小儿气管插管时的气道和循环反射。 Purpose Ebenin (Dexmedetomidine Hydrochloride Injection) is a new generation of α2 adrenergic receptor agonists that agonize the α2 adrenergic receptor (α2: α1 = 1620: 1) by highly selective Sedation, analgesia, anti-sympathetic without respiratory depression, compared with placebo in this paper, for pediatric tonsils, adenotonsillectomy sedative analgesic anti-anxiety compared to observe the clinical effect. Methods A total of 51 children with tonsillitis and adenoid resection undergoing general anesthesia were randomly divided into two groups: 26 cases in the Ebenin group, placebo Group of 25 cases. Epidural administration of 0.5 μg / kg of Ebeninib (Group D) (n = 26) was slowly initiated in one peripheral vein group (n = 25) in the other group before bolus intubation. 60s injection is completed. Patients were recorded on the choking cough frequency, and recorded in patients with laryngospasm, bronchial spasm or oxygen deficiency and inadequate tracheal intubation were recorded before, during and after patients were recorded oxygen saturation, heart rate, respiratory rate, systolic blood pressure And diastolic pressure. Need to record anesthesia wake up time. Results The median cough scores of the two groups were 1 (1 ~ 3) and 2 (1 ~ 4) respectively (P <0.05). However, there was no difference between the two groups in the rate of breath-hold or oxygen-deficiency. Heart rate, systolic and diastolic blood pressure increased during bronchoscopic operation in both groups (P <0.05), but were less pronounced in the Elbenin group. Two groups of patients anesthesia recovery time is basically the same. Conclusions This study found that a single intravenous injection of ebenecine reduced airway and circulatory reflexes in children with endotracheal intubation.