【摘 要】
：
脑缺血再灌注损伤是在遭受一定时间缺血的脑部组织细胞恢复血流后,组织损伤程度迅速增剧的情况,作为引起多种脑血管疾病重要的病理生理机制,它是一个多环节、多因素、多途径
【机 构】
：
上海中医药大学附属普陀医院中医综合科,上海200062;上海中医药大学附属岳阳中西医结合医院神经内科,上海200437
论文部分内容阅读
脑缺血再灌注损伤是在遭受一定时间缺血的脑部组织细胞恢复血流后,组织损伤程度迅速增剧的情况,作为引起多种脑血管疾病重要的病理生理机制,它是一个多环节、多因素、多途径损伤的级联反应过程.中医药是祖国文化瑰宝,在治疗脑血管疾病方面体现其显著疗效和特色优势,近年关于中医药干预脑缺血模型,治疗缺血性脑卒中的实验、临床研究日益增多.该文从脑缺血再灌注损伤后脑血流量改变,氧自由基产生,兴奋性氨基酸的神经毒性,钙超载,炎症反应及血脑屏障的破坏六个方面,对脑缺血再灌注损伤不同阶段的病理机制进行阐述,同时针对中药复方及中药单体在不同病理环节中的神经保护作用,就防治脑缺血再灌注损伤的实验研究现状予以综述,并围绕研究中存在的问题进行讨论和展望.
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