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伴有粘膜损害的重型大疱性多形红斑被称之为Stevens-Johnson(下称S-J)综合征.其特点是皮肤粘膜对称分布的红斑、大疱和化脓性损害,最易受累的粘膜是结合膜.据Ashby等81例的统计,有91%眼部受累.S-J综合征的眼部损害可分为:急性期:伴有水疱、溃疡的急性结膜炎和炎性膜的形成.还可发生继发感染引起化脓性结膜炎.早期的结膜炎是全结膜炎,伴有整个结膜粘液腺及其邻近附件如睑板腺、睫毛囊和泪腺管的损害.早期还可发生角膜糜烂引起严重羞明.眶周肿胀是急性期的突出表现.睑缘炎明显而严重的病例,睫毛连同深层组织可呈薄纸状剥脱.中期:睑球粘连是最常见的早期并发症,其程度轻重不一.粘连的发生取决于球、睑结膜溃疡面接近的机会,这种情况并不少见.该期损害的角膜继发感染后可导致虹膜炎和前房蓄脓.由于感染扩
Severe bullous erythema with mucosal lesions is called Stevens-Johnson (hereinafter referred to as SJ) syndrome, which is characterized by symmetrical distribution of erythema, bullous and suppurative lesions of mucocutaneous mucosa, the most vulnerable mucosa is Combined with film.According to Ashby and other 81 cases of statistics, 91% of the ocular involvement.SJ syndrome ocular damage can be divided into: acute phase: accompanied by blisters, ulcers, acute conjunctivitis and inflammatory membrane formation. Secondary infection causes purulent conjunctivitis .Conjunctivitis is the early conjunctivitis, accompanied by the entire conjunctival mucus gland and its adjacencies such as meibomian gland, eyelash folds and lacrimal duct damage. Early corneal erosion can also cause serious Shame Ming Periorbital swelling is a prominent manifestation of the acute phase of blepharitis, severe and severe cases, eyelashes with deep tissue can be thin paper-like exfoliation.Middle: bulla adhesion is the most common early complications, varying degrees of severity Occurrence of adhesions depends on the chance that the ball or conjunctival ulcer is approaching, and it is not uncommon for this lesion to occur after secondary infection of the cornea, resulting in iritis and anterior chamber suppuration.