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[Objective] To explore the antagonistic effects of curcumin on formaldehyde-induced oxidative damage in cell. [Method] A549 cell were used as experimental materials, experiment was divided into normal control group, 0.1 mmol/L formaldehyde exposure group, and curcumine group (0.1 mmol/L formaldehyde + 2.5-20.0 mg/L curcumine). NOS, MDA, SOD and GSH-PX activities were detected in A549 cells. [Result] SOD, NOS and GSH-Px activities in A549 cells in formaldehyde exposure group were(21.79±1.13), (1.88±0.16) and (27.83±0.2)U/mg prot, respectively. Compared with control group, SOD, NOS and GSH-Px activities were significantly decreased (P<0.05), but MDA content increased significantly(P<0.05).Compared with the formaldehyde exposure group, GSH-Px activity in curcumin groups enhanced; and MDA content decreased (P<0.05). Compared with control group, differences in GSH-Px activity and MDA content in 40 mg/L curcumine group had no statistical significance (P>0.05). [Conclusion] Curcumin could enhance the antioxidant enzyme activity in A549 cells, showing certain dose-effect relationship.
[Objective] To explore the antagonistic effects of curcumin on formaldehyde-induced oxidative damage in cell. [Method] A549 cells were used as experimental materials, experiment was divided into normal control group, 0.1 mmol / L formaldehyde exposure group, and curcumine group SOD and GSH-Px activities in A549 cells in A549 cells. [Result] SOD, NOS and GSH-Px activities in A549 cells in formaldehyde exposure group were (21.79 ± 1.13), (1.88 ± 0.16) and (27.83 ± 0.2) U / mg prot, respectively. Compared with control group, SOD, NOS and GSH-Px activities were significantly decreased Compared with GSH-Px activity in curcumin groups enhanced; MDA content decreased (P <0.05) .Compared with the formaldehyde exposure group, GSH-Px activity in curcumin groups enhanced; / L curcumine group had no statistical significance (P> 0.05). [Conclusion] Curcumin could enhance the antioxidant enzyme activity in A549 cells, showing certain dose-effect relationship.