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目的探讨非小细胞肺癌(NSCLC)组织中CTEN蛋白、转化生长因子β1(TGF-β1)和E-钙黏蛋白的表达及其临床意义。方法采用免疫组化法检测120例NSCLC组织中CTEN基因、TGF-β1和E-钙黏蛋白的表达水平,分析其与临床病理学特征的关系。结果CTEN、TGF-β1和E-钙黏蛋白的阳性表达率分别为68.3%、48.3%和29.2%;其表达量与肿瘤大小、分化程度、TNM分期及有无淋巴结转移密切相关(P<0.05)。CTEN的表达与TGF-β1呈正相关(r=0.264,P=0.004),TGF-β1与E-钙黏蛋白的表达呈负相关(r=-0.254,P=0.005)。CTEN基因蛋白的表达水平与患者的总生存期相关,并可作为一个独立的因素用于判断NSCLC患者的预后(P<0.05)。结论CTEN、TGF-β1和E-钙黏蛋白可能在NSCLC的发生、发展中起重要作用,对评估NSCLC患者的预后具有一定价值。
Objective To investigate the expression of CTEN protein, transforming growth factor β1 (TGF-β1) and E-cadherin in non-small cell lung cancer (NSCLC) and its clinical significance. Methods Immunohistochemistry was used to detect the expression of CTEN, TGF-β1 and E-cadherin in 120 NSCLC tissues. The relationship between them and the clinicopathological features was analyzed. Results The positive rates of CTEN, TGF-β1 and E-cadherin were 68.3%, 48.3% and 29.2%, respectively. The positive expression rates of CTEN, TGF-β1 and E-cadherin were correlated with tumor size, differentiation, TNM stage and lymph node metastasis ). The expression of CTEN was positively correlated with TGF-β1 (r = 0.264, P = 0.004). There was a negative correlation between the expression of TGF-β1 and E-cadherin (r = -0.254, P = 0.005). The expression level of CTEN gene protein correlated with the overall survival of patients, and could be used as an independent factor in the prognosis of patients with NSCLC (P <0.05). Conclusion CTEN, TGF-β1 and E-cadherin may play an important role in the occurrence and development of NSCLC, and may be of value in assessing the prognosis of patients with NSCLC.