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目的 :检测胃腺癌组织中微血管密度 (MVD)、血管内皮细胞生长因子 (VEGF)与胀亡。方法 :用免疫组织化学方法检测 4 0例胃腺癌组织中MVD和VEGF的表达 ,用透射电镜检测胃癌细胞的胀亡情况。结果 :4 0例胃癌组织中 ,MVD 9~ 78,平均 (36 .5± 1 6 .5 ) ;1 6例VEGF表达阳性 ,阳性率为 4 0 %。胃癌组织中可出现不同时期的胀亡细胞 ,胀亡指数为 (2 .5 94± 0 .1 5 7)。VEGF的表达与胀亡细胞的发生呈负相关 (P <0 .0 5 )。结论 :胃癌组织中血管形成抑制了细胞胀亡的发生。
Objective: To detect the microvessel density (MVD), vascular endothelial growth factor (VEGF) and inflamation in gastric adenocarcinoma. Methods: The expressions of MVD and VEGF in 40 cases of gastric adenocarcinoma were detected by immunohistochemistry. The expansion and contraction of gastric cancer cells were detected by transmission electron microscopy. Results: Among 40 gastric cancer samples, the MVD ranged from 9 to 78, with an average of (36.5 ± 16.5) and 16 (VEGF) positive, with a positive rate of 40%. Inflammatory cells in different stages of gastric cancer may appear, with a swelling index of (2 .594 ± 0.157). The expression of VEGF was negatively correlated with the occurrence of inflamed cells (P <0.05). Conclusion: The angiogenesis in gastric cancer inhibits the occurrence of cell infiltration.