论文部分内容阅读
以往认为,病毒感染仅在糖尿病发生中起作用。最近用非肥胖型糖尿病小鼠(NOD)进行研究发现,淋巴细胞性脉络丛脑膜炎病毒(LCMV)与特定的免疫细胞相互作用可预防小鼠分泌胰岛素的细胞受破坏。Old-stone 等报道,由于非肥胖型糖尿病小鼠具有典型的胰岛自身免疫损伤,伴有淋巴细胞浸润和胰岛β细胞破坏,小鼠常在出生后6周发生糖尿病;但是,若将小鼠预先感染淋巴细胞性脉络丛脑膜炎病毒,小鼠几乎不发病。其中出生后即感染 LCMV 的小鼠,在生后9个月内发病率为0％;生后6周感染此病毒的小鼠,同期内发病率仅为6％;而未感染该病毒的小鼠发病率则高达95％。有资料提示,此型糖尿病可能仅涉
In the past that the virus infection only plays a role in the occurrence of diabetes. A recent study with non-obese diabetic mice (NOD) found that the interaction of lymphocytic choriomeningitis virus (LCMV) with specific immune cells can prevent the destruction of insulin-secreting cells in mice. Old-stone et al. Reported that mice often developed diabetes 6 weeks after birth due to the typical islet autoimmune damage associated with lymphocyte infiltration and islet β cell destruction in non-obese diabetic mice; however, Infected with lymphocytic choriomeningitis virus, mice almost no onset. The mice infected with LCMV at birth were found to have a 0% incidence within 9 months after birth. The mice infected with this virus at 6 weeks after birth had an incidence of only 6% in the same period, while those not infected with the virus The incidence of rats is as high as 95%. Data suggest that this type of diabetes may only be involved