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为了探讨转化生长因子 -β1(TGF -β1)在脂肪肝患者肝纤维化发病机理中的作用 ,采用ELISA法测定 6 8例脂肪肝患者血清TGF -β1活力和层粘蛋白 (LN)含量 ,并与 2 0例健康成人比较 ,结果显示 :脂肪肝患者LN与对照组差异无显著性 ,但酒精性脂肪肝组有显著升高 (P <0 .0 5 ) ;酒精性脂肪肝组和非酒精性脂肪肝组的TGF -β1与对照组相比 ,均显著升高 (P分别 <0 .0 1,0 .0 5 ) ,相关性分析表明 ,脂肪肝患者血清TGF -β1与LN呈正相关 (r =0 .4911)。认为血清中TGF-β1活力可作为脂肪肝患者肝纤维化诊治的辅助因子
To investigate the role of transforming growth factor-β1 (TGF-β1) in the pathogenesis of hepatic fibrosis in patients with fatty liver, the serum levels of TGF-β1 and laminin (LN) in 68 patients with fatty liver were measured by ELISA Compared with 20 healthy adults, the results showed that there was no significant difference between LN group and control group in patients with fatty liver, but alcoholic fatty liver group was significantly higher (P <0.05); alcoholic fatty liver group and non-alcoholic group The levels of TGF-β1 in the fatty liver group were significantly higher than those in the control group (P <0.01, 0.05, respectively). Correlation analysis showed that serum TGF-β1 was positively correlated with LN in patients with fatty liver r = 0 .4911). Serum TGF-β1 activity that can be used as diagnosis and treatment of liver fibrosis in patients with cofactors