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目的:探讨Fascin蛋白在人肺癌组织中的表达及临床意义。方法:收集63例肺癌标本及相关临床病理资料,以Western blot方法检测肺癌组织、癌旁组织及正常组织中Fascin蛋白的表达情况。结果:Fascin蛋白在肺癌组织中的表达明显高于其在肺正常组织中的表达(P<0.05),而其表达与肺癌的临床分期(P<0.05)、淋巴结转移情况(P<0.05)、组织分化程度(P<0.05)有关;在肺癌的分型中,Fascin蛋白在鳞癌与腺癌之间的表达水平有显著性差异(P<0.05);Fascin蛋白的表达与患者的性别、年龄、吸烟史无关(P>0.05)。结论:Fascin蛋白在肺癌中的高表达,是肺癌分化差、恶性程度高的标志,并与淋巴结转移有关,以Fascin蛋白为靶点可能为肺癌的治疗提供新的思路。
Objective: To investigate the expression of Fascin protein in human lung cancer and its clinical significance. Methods: Sixty-three lung cancer specimens and related clinicopathological data were collected. The expression of Fascin protein in lung cancer tissues, adjacent non-cancerous tissues and normal tissues was detected by Western blot. Results: The expression of Fascin protein in lung cancer tissues was significantly higher than that in normal lung tissues (P <0.05), while the expression of Fascin was correlated with the clinical stages (P <0.05), lymph node metastasis (P <0.05) (P <0.05). In the classification of lung cancer, there was a significant difference in the expression of Fascin protein between squamous cell carcinoma and adenocarcinoma (P <0.05). The expression of Fascin protein correlated with the sex, age , Smoking history has nothing to do (P> 0.05). Conclusion: The high expression of Fascin protein in lung cancer is a marker of poorly differentiated and malignant lung cancer, and is related to lymph node metastasis. Fascin protein may provide a new idea for the treatment of lung cancer.