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目的比较卡前列素氨丁三醇及垂体后叶素在腹腔镜子宫肌瘤剔除术中的止血效果。方法选取晋江市医院2014年1月—2016年3月收治的行腹腔镜子宫肌瘤剔除术患者90例,随机分成卡前列素氨丁三醇组(A组)45例和垂体后叶素组(B组)45例。A组患者应用卡前列素氨丁三醇止血,B组患者应用垂体后叶素。比较两组患者出血量、手术时间、不同时间点(注射后15 min、30 min、45 min和180 min)血压水平,观察不良反应发生情况。结果 A组患者出血量少于B组,手术时间短于B组(P<0.05)。用药后15 min,A组患者收缩压、舒张压水平低于对照组(P<0.05);用药后30 min、45 min及180 min,两组患者血压比较,差异无统计学意义(P>0.05)。两组患者均无严重不良反应发生。结论卡前列素氨丁三醇在腹腔镜子宫肌瘤剔除术中的止血效果优于垂体后叶素,可有效减少患者术中出血量,缩短手术时间,安全性高。
Objective To compare the effect of carboprost trometamol and vasopressin on hemostasis in laparoscopic myomectomy. Methods 90 patients underwent laparoscopic myomectomy in Jinjiang Hospital from January 2014 to March 2016 were randomly divided into carboprost (A group) and pituitrin group (Group B) 45 cases. A group of patients with cardoprost tromethamine hemostasis, B group of patients with pituitrin. Blood pressure, operation time, blood pressure levels at different time points (15 min, 30 min, 45 min and 180 min after injection) were compared between two groups to observe the incidence of adverse reactions. Results The bleeding volume of group A was less than that of group B, and the operation time was shorter than that of group B (P <0.05). The systolic blood pressure and diastolic blood pressure in group A were lower than those in control group at 15 min after drug administration (P <0.05), but there was no significant difference in blood pressure between the two groups at 30 min, 45 min and 180 min ). No serious adverse reactions occurred in both groups. Conclusion The effect of carboprost trometamol in laparoscopic myomectomy is better than pituitrin, which can effectively reduce the amount of intraoperative blood loss, shorten the operation time and have high safety.