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目的：通过对大剂量中枢抑制药物中毒患者体内代谢动力学过程的分析研究，了解该类药物在超大剂量服药后体内代谢及清除的特点，从而为临床抢救提供依据，也为某些药物在超过治疗剂量后体内处置过程的研究提供参考。方法：对临床严重中毒的患者首先经定性确证，且血中药物浓度达到中毒或致死范围，临床资料完整的病例进行连续血浓度定量监测，血药浓度时间数据用３Ｐ８７药动学程序进行模型拟合并计算药动学参数。结果：在大多数肝肾功能正常的青壮年患者中，尽管所服剂量大，血中浓度很高，吸收相的参数与文献值相比差异较大，少数患者出现双峰现象，但消除半衰期改变不大，甚至小于文献值，且代谢符合线性动力学过程。结论：大剂量中枢抑制药物中毒的患者在血药浓度监测下，根据血清中药物浓度及其患者的代谢和排泄情况，采用相应的治疗措施，绝大多数患者体内的药物仍然按线性动力学过程代谢，且代谢半衰期比文献正常值缩短，一般患者预后良好。
OBJECTIVE: To understand the metabolism and clearance of these drugs in vivo after taking large doses of drugs by analyzing and analyzing the in vivo pharmacokinetics of high-dose central drugs in patients with poisoning, so as to provide a basis for clinical rescue and also for certain drugs in excess of Therapeutic dose of the body after the disposal process for reference. Methods: The patients with severe clinical poisoning were firstly confirmed by qualitative analysis, and the concentration of blood in the blood reached the range of poisoning or lethality. The blood samples with complete clinical data were used for the quantitative monitoring of blood concentration. The blood concentration-time data were modeled by 3P87 pharmacokinetics program Fitting and calculation of pharmacokinetic parameters. Results: In most of the young patients with normal liver and kidney function, despite the large dose and the high concentration of blood, the parameters of the absorption phase were quite different from those of the literatures. The bimodal phenomenon appeared in a few patients, but the elimination half-life Change little, even less than the value of the literature, and the metabolism consistent with the linear kinetic process. CONCLUSIONS: In patients with high dose of central suppression of drug poisoning, blood concentration monitoring, according to the serum concentration of drugs and their patients’ metabolism and excretion, the corresponding treatment measures, the vast majority of patients with the drug is still in accordance with the linear kinetic process Metabolism, and metabolic half-life shorter than the normal literature, the general prognosis of patients with good.