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目的 :为了研究中药免不 1号治疗免疫性不孕症作用机理。方法 :用精子抗原免疫昆明种雌小鼠 ,建立免疫不孕症动物模型 ,饲喂中药复方免不 1号 ,观察抗精子抗体指标、组织学指标、免疫细胞化学指标和妊娠指标。结果 :免不 1号能降低卵巢免疫复合物沉积 ;免不 1号能明显降低小白鼠血清抗精子抗体 ,且停药后抗体反跳幅度小 ;免不 1号明显提高动物的妊娠 ,每胎仔数明显高于模型组 (P <0 0 5 )及西药组 (P <0 0 5或P <0 0 1)。结论 :免不 1号可能通过清除卵巢免疫复合物沉积 ,降低免疫复合物对组织的损伤 ,并降低血清 ,宫颈黏液AsAb ,有利于提高小鼠的妊娠。
Purpose : To study the mechanism of the treatment of immune infertility with Chinese Herb No.1. METHODS: Kunming female mice were immunized with sperm antigen, an animal model of immune infertility was established, and Chinese herbal compound Fufang No. 1 was fed to observe anti-sperm antibody, histological, immunocytochemical and pregnancy indicators. RESULTS: Yibu1 could reduce the deposition of ovarian immune complexes; Yibu1 could significantly reduce serum anti-sperm antibodies in mice, and the amplitude of antibody rebound after discontinuation was small; Yibu1 could significantly improve the animal’s pregnancy. The number was significantly higher in the model group (P <0 05) and western medicine group (P <0 05 or P <0 01). Conclusion : No.1 may reduce the damage of immune complexes by reducing the deposition of immune complexes in the ovary, and reduce serum and cervical mucus AsAb, which is helpful to improve the pregnancy of mice.