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秋水仙碱作为保肝药能阻止胞浆微管的聚集。抑制胶原蛋白跨幞转运,刺激人工培养的滑液组织中胶原酶的产生,对肝细胞胞浆膜有稳定作用;水飞蓟的保肝作用也早已得到证实,其对各种肝毒性物质如α-蝇蕈碱、硫代乙酰胺、半乳糖胺、乙醇、扑热息痛造成的肝损害均有抑制作用,作用机制可能与捕获肝细胞产生的毒性自由基、稳定肝细胞膜及提高细胞的抗渗、抗溶能力有关。本文对上述两药的保肝作用进行了对比研究。实验采用体重50～100g的雄性Wistar大鼠,腹腔
Colchicine as a hepatoprotectant can prevent the accumulation of cytoplasmic microtubules. Inhibiting collagen transport across the tendon stimulates the production of collagenase in the cultured synovial tissue and stabilizes the hepatic cytoplasmic membrane; the hepatoprotective effects of silymarin have also been proven for a long time on various hepatotoxic substances such as Alpha-muscarinic acid, thioacetamide, galactosamine, ethanol, and paracetamol all have an inhibitory effect on liver damage. The mechanism may be related to the capture of toxic free radicals produced by hepatocytes, stabilization of hepatocyte membranes, and enhancement of cell impermeability. Resistance to dissolution. In this article, we compared the hepatoprotective effects of the above two drugs. Experiments using male Wistar rats weighing 50 to 100 g, abdominal cavity