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目的:研究苦皮藤根皮石油醚提取物的化学成分。方法:通过石油醚提取,提取物用80%甲醇水溶解,石油醚反复萃取除杂,80%甲醇水部分采用硅胶柱色谱法、重结晶和半制备HPLC制备等多种方法分离纯化,通过NMR数据解析,参考已知文献,鉴定化合物的结构。结果:从苦皮藤根皮石油醚提取物中分离到7个化合物,分别为儿茶素[(+)-catechin,1],表儿茶素[(-)-epicatechin,2],9,12-烯-3β-齐墩果烷(9,12-diene-3β-hydroxyolean,3),β-谷甾醇(β-sitosterol,4),油酸(oleic acid,5),triptohypol F(6),wiforsinsine B(7)。结论:化合物5,6,7为首次从苦皮藤根皮中分离得到,化合物6,7为首次从南蛇藤属中分离得到。
OBJECTIVE: To study the chemical constituents of the extract of bortex petiole oil. Methods: The extracts were extracted with petroleum ether, the extracts were dissolved in 80% methanol and extracted repeatedly with petroleum ether. The fractions were purified by silica gel column chromatography, recrystallization and semi-preparative HPLC. Data analysis, reference to known literature, identification of the structure of compounds. Results: Seven compounds were isolated from the root bark petroleum ether extract of Cortex pendula. They were catechin (1), epicatechin (2), catechin 3,12-diene-3β-hydroxyolean (3), β-sitosterol (4), oleic acid (5), triptohypol F wiforsinsine B (7). Conclusion: Compounds 5,6,7 were isolated from the root bark of Bitter bark for the first time. Compounds 6 and 7 were isolated from Celastrus for the first time.