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目的探讨CD28和可诱导共刺激分子(ICOS)在狼疮性肾炎患者外周血T细胞上的表达。方法狼疮性肾炎患者40例;其中,Ⅰ型肾炎4例,Ⅱ型肾炎9例,Ⅲ型肾炎8例,Ⅳ型肾炎15例,Ⅴ型肾炎4例。流式细胞术检测CD4~+T细胞表面CD28和ICOS的表达。结果与Ⅰ型肾炎者比较,Ⅲ型和Ⅳ型狼疮性肾炎患者外周血CD4~+T细胞表面CD28表达下调,ICOS表达上调(P<0.05或P<0.01)。结论Ⅲ型和Ⅳ型狼疮性肾炎患者外周血T细胞上ICOS和CD28表达异常,可作为狼疮性肾炎患者治疗和预后判断的指标。
Objective To investigate the expression of CD28 and inducible costimulatory molecule (ICOS) on peripheral blood T cells in patients with lupus nephritis. Methods: Forty patients with lupus nephritis were included. Among them, 4 were type I nephritis, 9 were type II nephritis, 8 were nephritis III, 15 were nephritis IV and 4 were Ⅴ nephritis. Flow cytometry was used to detect the expression of CD28 and ICOS on CD4 ~ + T cells. Results Compared with those with type I nephritis, the expression of CD28 on the surface of CD4 ~ + T cells in type Ⅲ and Ⅳ patients with lupus nephritis was down-regulated and the expression of ICOS was up-regulated (P <0.05 or P <0.01). Conclusions The expressions of ICOS and CD28 on peripheral blood T lymphocytes in patients with type Ⅲ and Ⅳ lupus nephritis are abnormal and may be used as indexes for the treatment and prognosis of patients with lupus nephritis.