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活性氧是动脉粥样硬化血管炎症中多种信号转导系统的主要调节者,贯穿于脂质条纹的形成、病变进展到最终斑块破裂的全过程。线粒体呼吸链是体内活性氧的主要来源,同时也是活性氧的主要靶点,从而导致线粒体功能受损。此外,在无动脉粥样硬化危险因素的线粒体疾病患者中,通常早期即可出现血管并发症。作者就线粒体功能障碍与动脉粥样硬化发生之间的关系作一综述。
Reactive oxygen species (ROS) are the main regulators of a variety of signal transduction systems in atherosclerotic vascular inflammation throughout the formation of lipid streaks and progression of the disease to the eventual rupture of the plaque. Mitochondrial respiratory chain is the main source of reactive oxygen species in the body, but also the main target of reactive oxygen species, resulting in mitochondrial dysfunction. In addition, in patients with mitochondrial disease that is not a risk factor for atherosclerosis, vascular complications usually occur early. The author reviews the relationship between mitochondrial dysfunction and atherosclerosis.