HIF-1相关论文
背景最新数据研究分析指出,全球现存糖尿病患者占总人口的9.3%,且有逐年上涨的趋头,而国内患病率较这个数字稍高,约为10.9%。糖尿......
肿瘤血管生成是肿瘤生长的必要条件。在肿瘤组织的血管生成中,血管内皮生长因子（vascular endothelial growth factor,VEGF）起到了至......
A smart O2-generating nanocarrier optimizes drug transportation comprehensively for chemotherapy imp
Drug transportation is impeded by various barriers in the hypoxic solid tumor,resulting in compromised anticancer effica......
目的:探究不同处理时间、浓度的内皮素-1（ET-1,endothelin-1）刺激大鼠软骨细胞过程中对缺氧诱导因子-1、2（HIF-1、2）基因表达水平的影......
Visualizing nitric oxide-dependent HIF-1 activity under hypoxia with a lipid droplet-targeting fluor
Evaluating the correlation between hypoxia inducible factor 1 (HIF-1) and nitric oxide (NO) generated under hypoxia is o......
背景:缺氧诱导因子是骨缺氧微环境中关键的基因表达调节因子,了解缺氧诱导因子在骨形成、骨重塑中的作用机制及其对骨稳态失衡类疾......
多发性硬化（Multiple Sclerosis,MS）是一种累及中枢神经系统的自身免疫性疾病,目前病因不明,可能与遗传、居住环境、饮食、营养以及......
人源NDRG2（又名SYLD或KIAA1248）是我室在1999年利用基于PCR的消减杂交技术进行神经胶质瘤与正常脑组织的基因表达差异研究时发现的一......
目的 探讨生物钟基因(MCLK)1对HT22细胞凋亡及磷脂酰肌醇-3-激酶(PI3K)/蛋白激酶B(Akt)信号通路的影响.方法 构建靶向MCLK1-shRNA......
The Association of depressed angiogenic factors with reduced capillary density in Rhesus monkey mode
Depressed capillary density is associated with myocardial ischemic infarction,in which hypoxia-inducible factor 1α(HIF-......
低氧诱导因子(hypoxiainduciblefactors,HIFs)属于螺旋-环-螺旋(bHLH)转录因子家族,包括三种亚型(HIF-1,HIF-2和HIF-3),目前的研究......
SIRT1 expression is refractory to hypoxia and inflammatory cytokines in nucleus pulposus cells: Nove
Backgrounds:Hypoxia and a marked increase in inflammatory cytokines are common hallmarks of intervertebral disc degenera......
目的 间歇低氧对哮喘动物模型炎症与气道重塑影响.监测重塑指标、探讨间断低氧对重塑影响.观察NF-κBp65、HIF-1α变化探讨其在气......
Aim: Oligomer procyanidins (F2, degree of polymerization 2-15), a natural fraction isolated from grape seeds, was demons......
...
A research on the mechanism of TH-302 in hypoxic environment and TH-302 combined with radiation appl
Objective Tumors often contain hypoxic regions resistant to chemo-and radiotherapy.TH-302 is an investigational hypoxia-......
Cisplatin Triggers HIF-1-dependent MIR-424 Upregulation that Confers Chemo-resistance by Targeting U
Chemotherapy resistance of tumor cells is one of the major hurdles for bladder cancer treatment.The recent advances show......
TS-1 Enhances the Effect of Radiotherapy by Suppressing Radiation-induced HIF-1 Activation and inDuc
Purpose: The therapeutic effect of concurrent chemoradiotherapy with TS-1 has been confirmed in various solid tumors; ho......
氧化应激是一种普遍存在的对细胞稳态的改变,主要由细胞内产生的多余活性氧引起。通常细胞根据不同氧化应激水平对基因表达谱整体......
19-DIH,a novel cardenolide,was isolated from the leaves of Calotropis gigantea.Our group have isolated and identified a ......
Perillyl alcohol efficiently scavenges activity of cellular ROS and inhibits the translational expre
Perillyl alcohol (POH) is a dietary monoterpene present in a variety of plants with a pure or mixed form,and it is one o......
...
目的 研究盐酸小檗碱对乏氧食管癌细胞的放射增敏作用.方法 通过MTT法检测盐酸小檗碱对食管癌ECA-109细胞生长的抑制;克隆集落形成......
目的 为探讨黄芪-红参改善糖尿病视网膜病变的作用机制.方法 运用网络药理学方法,通过中药系统药理学数据库(TCMSP)筛选出黄芪-红......
目的：探讨高压氧对移植皮瓣毛细血管增殖作用的机制。
方法：12只家兔随机分为对照组和实验组(HBO组)。建立家兔背部随意皮瓣模型......
Hypoxia-inducible factor-1(HIF-1)is a key heterodimeric transcription factor for the cellular adaptive response to hypox......
恶性肿瘤是一种严重威胁人类健康的常见病和多发病。目前人类因恶性肿瘤引起的死亡占所有疾病死亡率的第二位，仅次于心脑血管疾......
目的：缺氧诱导因子1在肿瘤中的研究进展及与对肿瘤放化疗敏感性影响的机制。方法：论述。结果：缺氧诱导因子1是参与机体氧稳态失衡......
目的 探讨原发性肝癌(PHC)肝动脉灌注化疗栓塞术(TACE)后HIF-1与VEGF表达变化及意义。方法 采用免疫组织化学(IHC)Elivison法......
...
...
肿瘤的放射敏感性与放射治疗疗效密切相关,而肿瘤内乏氧又被认为对放射敏感性有重要的影响.乏氧诱导因子-1(HIF-1)是调节细胞适应......
0 引言rn鼻咽癌是头颈部常见恶性肿瘤之一,其局部复发及远处转移一直是影响鼻咽癌患者长期存活的主要因素.而肿瘤的侵袭与转移是受......
目的探讨HIF-1在介导间充质干细胞动员治疗缺血缺氧性脑损伤中的作用及机理。方法(1)小鼠MSCs的体外培养及鉴定:利用贴壁筛选法获......
目的:通过参芪复方对高糖“代谢记忆”内皮细胞的影响观察,从细胞增殖情况、HIF-1及IL-6表达变化情况探讨参芪复方抑制高糖内皮细......
背景:在外科手术中,为了减轻缺血再灌注损伤对器官影响,研究先后发现了缺血预处理(Ischemic Preconditioning,IPC)和远端缺血预处......
糖酵解代谢途径和三羧酸循环途径是生物提供能量和中间代谢物产生的核心枢纽,是真核生物和异养生物中普遍存在的保守的基本代谢途......
目的 观察不同CO2气腹压力条件下,大鼠移植性肝癌中缺氧诱导因子(HIF)-1α与血管内皮生长因子(VEGF)表达的变化.方法 制作大鼠Walk......
目的探讨原发性肝癌(HCC)患者索拉非尼联合经肝动脉化疗栓塞(TACE)术治疗的有效性及对患者低氧诱导因子-1α(HIF-α)、白介素细胞-......
目的:探究奥曲肽(Oct)在胰岛移植早期缺氧环境下对胰腺外分泌细胞AR42J的影响及可能机制。方法:将胰岛β细胞Min6分为常氧培养组和......
目的探讨慢性阻塞性肺疾病(COPD)患者血清HIF-1α、caspase-3、Hcy水平与认知障碍的相关性及临床意义。方法收集简阳市人民医院201......
Significance of detection of serum HIF-1 α and β-catenin in rat model of vascular calcification in c
Objective:To investigate the association between serum HIF-1α,β-catenin levels and the vascular calcification in the r......
