论文部分内容阅读
目的探讨ATP结合盒转运子A1(ABCA1)R219K基因多态性与2型糖尿病(T2DM)合并冠心病(CHD)的关系。方法采用多聚酶链反应-限制性片段长度多态性法检测83例健康对照者(NC组)、72例单纯T2DM患者(CHD-组)、71例T2DM合并CHD患者(CHD+组)ABCA1219位点的多态基因型。结果在NC组、CHD-组、CHD+组中,KK基因型分布为19.3%、16.7%、4.2%;CHD+组与NC组、CHD-组KK基因型频率差异有统计学意义(P<0.05)。K等位基因频率分别为42.2%、38.9%、31.7%,三组间差异无统计学意义。在糖尿病患者中,KK基因型携带者的血浆HDL-C水平显著高于RR型,其差异有统计学意义(P<0.05)。结论ABCA1R219K基因多态性可能相关于T2DM并发的CHD。
Objective To investigate the association between ATP binding cassette transporter A1 (ABCA1) R219K gene polymorphism and type 2 diabetes mellitus (T2DM) with coronary heart disease (CHD). Methods Eighty-three healthy controls (NC group), 72 T2DM patients (CHD-group) and 71 CHD patients with CHD (CHD + group) were enrolled in this study. The level of ABCA1219 in CHD patients was detected by polymerase chain reaction-restriction fragment length polymorphism Polymorphic genotypes. Results The frequencies of KK genotypes in CHD group, CHD group and CHD + group were 19.3%, 16.7% and 4.2%, respectively. The frequencies of KK genotype in CHD + group and CHD- group were significantly different (P <0.05) . K allele frequencies were 42.2%, 38.9%, 31.7%, respectively, with no significant difference among the three groups. In diabetic patients, the level of plasma HDL-C in KK carriers was significantly higher than that in RR ones, with significant difference (P <0.05). Conclusion ABCA1R219K gene polymorphism may be related to T2DM complicated with CHD.