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目的:通过对原发性肝癌患者在介入治疗后血浆中DIC分子标志物的检测,探讨微小剂量肝素预防DIC的作用。方法:27例患者依就诊顺序编入肝素组(14例)及对照组(13例)。测定肝动脉插管栓塞化疗术后血浆组织因子、组织因子途径抑制物、凝血酶、抗凝血酶Ⅲ和D-二聚体含量。结果:介入治疗后早期肝素组组织因子途径抑制物、抗凝血酶Ⅲ和D-二聚体含量均明显增高。结论:早期应用肝素可以降低血液的高凝状态。
OBJECTIVE: To explore the role of minimal dose heparin in the prevention of DIC by detecting plasma markers of DIC in patients with primary liver cancer after interventional therapy. Methods: Twenty-seven patients were enrolled in the heparin group (14 cases) and the control group (13 cases) according to the order of visits. The contents of plasma tissue factor, tissue factor pathway inhibitor, thrombin, antithrombin III and D-dimer were measured after hepatic artery catheterization and embolization. RESULTS: After interventional therapy, the levels of tissue factor pathway inhibitors, antithrombin III and D-dimer in heparin group were significantly increased. Conclusion: Early application of heparin can reduce the hypercoagulable state of blood.