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摄入过量氟化物造成钙化组织中氟化物的蓄积。氟化物在河绵状骨蓄积,是因它表面积质量的比值要比骨皮质大得多。由于氟化物与骨中无机和有机成分相互作用,所以研究了接受高剂量氟化钠的家兔其骨皮质和海绵状骨的化学成分,对评价氟化物作用的特征很有意义。用体重为600～800 g家兔,每天饲给10mg/kg的NaF共12个月,分别于3,6,8,10和12个月时,每组用5只动物,从股骨取骨皮质;从骨盆带的髂嵴部取海绵状骨,除去骨髓。用1∶1的乙醚-丙酮混合液和丙酮制取股脂骨粉。测定骨粉的总氮和羟脯氨酸含量。
Ingestion of excess fluoride causes accumulation of fluoride in calcified tissue. Fluoride in the river bone-like bone accumulation, because of its surface area than the mass ratio of cortical bone is much larger. Due to the interaction of fluoride with the inorganic and organic components of bone, the study of the chemical composition of cortical and spongy bone in rabbits receiving high doses of sodium fluoride is of great interest in assessing the characteristics of fluoride. With a body weight of 600 ~ 800 g rabbits fed 10 mg / kg of NaF for 12 months, respectively, at 3, 6, 8, 10 and 12 months, with 5 animals in each group, ; From the iliac crest of the pelvic zone to take cavernous bone, remove the bone marrow. Using 1: 1 ether - acetone mixture and acetone Preparation of fat powder. Determination of total nitrogen and hydroxyproline content of bone meal.