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目的 探讨联合脏器切除术加围手术期三联序贯疗法 (STTS)综合治疗Ⅲb、Ⅳ期胃癌的可行性。 方法 对1989年2月～1998年8月间手术治疗的34例Ⅲb、Ⅳ期胃癌的临床资料及随访结果进行分析 ,其中联合脏器切除术加STTS治疗22例 (综合治疗组 ,获随访21例 ) ,单纯联合脏器切除治疗12例 (单纯手术组 ,获随访11例 )。结果 综合治疗组和单纯手术组的术后一、三、五年生存率分别为27.3 %、45.6%、36.4%和75.0%、25.0%、0,两组三、五年生存率的差别具有显著性意义 (均P<0.05) ;而并发症发生率分别为22.7%和16.7% ,两组间的差别无显著性意义 (P>0.05)。结论 联合脏器切除术加STTS综合治疗Ⅲb、Ⅳ期胃癌有望提高患者的远期生存率
Objective To investigate the feasibility of combined organ resection plus perioperative triple sequential therapy (STTS) for comprehensive treatment of stage IIIb and IV gastric cancer. Methods Clinical data and follow-up results of 34 cases of stage IIIb and IV gastric cancer surgically treated from February 1989 to August 1998 were analyzed. Among them, 22 cases were treated with combined organ resection plus STTS (combined treatment group, follow-up 21 For example), 12 patients were treated with simple organ resection alone (only 11 patients were followed up in the surgery group). Results The postoperative one-, three-, and five-year survival rates of the combined treatment group and the surgery alone group were 27.3%, 45.6%, 36.4%, and 75.0%, 25.0%, and 0, respectively. The difference in survival rates between the two groups was significant. Sexual significance (all P <0.05); and the incidence of complications were 22.7% and 16.7%, respectively, there was no significant difference between the two groups (P> 0.05). Conclusion Combined organ resection plus STTS combined treatment of stage IIIb and IV gastric cancer is expected to improve long-term survival of patients