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药物治疗作为目前治疗精神分裂症的主要干预手段之一,已成为研究的主要突破点。我国上市不久的“老药”-氨磺必利,为治疗精神分裂症的非典型抗精神病药物,作用机制主要为选择性地拮抗多巴胺D_2/D_3受体,竞争性拮抗5-羟色胺受体,高度选择性作用于边缘系统。该药独有的作用机制使其对精神分裂症的阳性症状、阴性症状、情感性精神障碍如:抑郁症、双相障碍、阿尔茨海默病精神行为、酒精性精神障碍等病症都具有确切的疗效,能有效地提高患者的生活质量,且极少引起锥体外系反应,对泌乳素影响小,对体重、血脂及血糖几乎无影响,临床耐受性较好,可选为治疗精神分裂症的一线使用药物。本文通过查阅相关文献,对氨磺必利的药理作用、临床应用、不良反应等方面做一综述。
As one of the main interventions in the treatment of schizophrenia, drug therapy has become the main breakthrough of the study. China soon listed “old drug ” - amisulpride, atypical antipsychotics for the treatment of schizophrenia, the mechanism of action is mainly selective antagonism of dopamine D 2 / D 3 receptors, competitive antagonism of serotonin Body, a highly selective role in the limbic system. The drug’s unique mechanism of action makes it positive for schizophrenia symptoms, negative symptoms, emotional disorders such as: depression, bipolar disorder, mental illness Alzheimer’s disease, alcoholic mental disorders and other diseases have the exact Of the curative effect, can effectively improve the quality of life of patients, and rarely cause extrapyramidal reactions, little effect on prolactin, almost no effect on body weight, blood lipids and blood glucose, clinical tolerance is better, the treatment of schizophrenia Symptomatic use of drugs. This article reviews the related literature on the pharmacological effects of amisulpride, clinical application, adverse reactions and so on.