重组合的人肿瘤坏死因子(TNF)是现今临床试验治疗中的一种抗肿瘤制剂。以前有关肿瘤坏死因子对肺和肝脏损害的报告有肺弥散功能轻微的可逆性下降及转氨酶和胆红质轻度增高。作者报告了两例在首次接受静脉注射肿瘤坏死因子后发生的少见的毒性反应——肺出血和严重的肝功能损害。第1例病人肺部孤立的转移瘤在TNF 治疗前15个月已切除,尽管肺部转移瘤出血可解释咯血,但系列胸片和CT 扫描未发现有肿瘤复发迹象。支气管镜检查亦未发现与广泛的肺实质出血相一致的 Recombination of human tumor necrosis factor (TNF) is an anti-tumor agent in the treatment of clinical trials today. Previous reports of lung neoplasms and hepatic damage with tumor necrosis factor showed a slight reversible reduction in lung diffusion and a slight increase in transaminase and bilirubin. The authors reported two rare toxic reactions that occurred after the first intravenous injection of tumor necrosis factor-pulmonary hemorrhage and severe liver damage. The isolated metastasis of the first patient’s lung was removed 15 months before TNF treatment. Although hemorrhage in the metastatic tumor of the lung may explain hemoptysis, there was no sign of tumor recurrence on the series of chest X-ray and CT scan. Bronchoscopy has not been found to be consistent with extensive pulmonary parenchymal hemorrhage