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目的:蛛网膜下腔出血后诱发的脑血管痉挛是神经科学中棘手的难题。由于目前脑血管痉挛的病理生理学机制尚未完全阐明,因此至今此方面临床治疗与预防工作开展得不够理想。近年来随着新的实验技术的发展与运用,国内外在脑血管痉挛中钾离子通道的研究方面屡有重大突破。此领域相关机制的明确,将对临床防治工作具有重大指导意义。文章根据目前国内外在此项目上的最新研究成果进行综述。资料来源:应用计算机检索Medline数据库1991-01/2005-12期间的相关文章,检索词为“Potassiumchannel,Cerebralvasospasm,Subarachnoidhemorrhage”,限定文章语言种类为English。同时计算机检索中国期刊全文数据库万方数据库1991-01/2005-12期间的相关文章,检索词为“钾离子通道,脑血管痉挛,蛛网膜下腔出血”,限定语言种类为中文。资料选择:对资料进行初审,选取以对蛛网膜下腔出血后脑血管痉挛病理生理机制研究中有关钾离子通道的文献,排除关于钾离子通道生物化学、基因等方面的研究。资料提炼:共收集到英文文献45篇,17篇符合纳入标准,收集到中文文献2篇,1篇符合纳入标准,对18篇有关对蛛网膜下腔出血后脑血管痉挛病理生理机制研究中有关钾离子通道的文献开始查找全文。资料综合:研究发现蛛网膜下腔出血后诱发的脑血管痉挛中血管壁细胞钾离子通道的生理状况出现异常变化,而运用钾离子通道激动剂和阻滞剂在动物实验中可以对脑血管痉挛的程度进行具有显著效果的干预。结论:钾离子通道在蛛网膜下腔出血后诱发的脑血管痉挛中具有重要的作用。对于钾离子通道的研究有可能为临床提供更多的治疗性干预措施。
Objective: Cerebral vasospasm induced after subarachnoid hemorrhage is a difficult problem in neuroscience. Due to the current pathophysiology of cerebral vasospasm has not been fully elucidated, so far the clinical treatment and prevention work carried out less than ideal. In recent years, with the development and application of new experimental techniques, there have been many major breakthroughs in the research of potassium channel in cerebral vasospasm at home and abroad. Clear mechanism in this area will be of great guiding significance for clinical prevention and treatment. The article summarizes the latest research results on this project at home and abroad. DATA SOURCES: A computer-based online search of the Medline database was conducted between January 1991 and December 2005 with the search term “Potassiumchannel, Cerebralvasospasm, Subarachnoidhemorrhage”. The restricted article language is English. At the same time, the computer search Chinese Journal Full-text Database Articles Database from January 1991 to December 2005 during the related articles, the search term is “potassium ion channels, cerebral vasospasm, subarachnoid hemorrhage”, the limited language type is Chinese. Data selection: The data were first reviewed and selected to study the pathophysiology of cerebral vasospasm after subarachnoid hemorrhage in the literature on potassium channels, excluding potassium channel biochemistry, genes and other aspects of research. DATA EXTRACTION: A total of 45 English articles were collected, 17 articles met the inclusion criteria, 2 articles were collected in Chinese and 1 article met the inclusion criteria, and 18 articles about the pathophysiological mechanism of cerebral vasospasm after subarachnoid hemorrhage The literature of ion channels begins to look up the full text. Data synthesis: The study found that subarachnoid hemorrhage induced cerebral vasospasm vascular cell wall potassium channel physiological conditions abnormal changes, and the use of potassium channel agonists and blockers in animal experiments can be on cerebral vasospasm With a significant effect on the degree of intervention. Conclusion: Potassium channel plays an important role in cerebral vasospasm induced after subarachnoid hemorrhage. Research on potassium channels may provide more therapeutic interventions for the clinic.