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目的 检测血管内皮生长因子(VEGF)在子宫内膜异位症(EM)中的表达,探讨其在EM发病机制中的作用。方法 应用免疫组化SP法测定35例异位内膜组织和30例正常子宫内膜组织(对照组)中VEGF的表达情况,并用组织学评分对实验结果进行半定量统计,比较其表达强度。结果 VEGF在异位内膜的腺体及间质细胞中均有表达,主要定位于细胞浆。分泌期EM患者VEGF的表达强度明显高于正常对照组,二者有显著性差异(P<0. 05)。结论 异位内膜组织中VEGF的过度表达与异位内膜组织的血管生成密切相关,VEGF在子宫内膜异位症的发生发展中发挥作用。
Objective To detect the expression of vascular endothelial growth factor (VEGF) in endometriosis (EM) and to explore its role in the pathogenesis of EM. Methods The expression of VEGF in 35 cases of ectopic endometrium and 30 cases of normal endometrium (control group) was detected by immunohistochemical SP method. The histological score was used to semi-quantitatively compare the experimental results and compare their expression intensity. Results VEGF was expressed in the ectopic endometrial glands and interstitial cells, mainly located in the cytoplasm. The expression of VEGF in secretory EM patients was significantly higher than that in the normal control group (P <0.05). Conclusion The overexpression of VEGF in ectopic endometrium is closely related to the angiogenesis of ectopic endometrial tissue. VEGF plays a role in the development of endometriosis.