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目的:评价万古霉素与清胰汤联用对重症急性胰腺炎及其防治继发感染的疗效。方法:选取2011年2月—2013年9月间诊治的重症急性胰腺炎患者56例,将其分为观察组(n=32)和对照组(n=24),两组患者均给予液体复苏、胃肠减压、抑制胰腺酶分泌,以及纠正水电解质、酸碱平衡、抗炎,并建立呼、吸气通道及净化血液等常规治疗,观察组患者予胃管灌注清胰汤和万古霉素治疗;比较两组患者经治疗后的临床症状和体征改善情况及不良反应的发生情况。结果:观察组患者显效率和总有效率分别为71.88%和93.75%,均明显高于对照组41.67%和79.17%,两组资料经比较其差异有统计学意义(P<0.05);观察组患者的继发感染率为12.5%,明显低于对照组37.5%(P<0.05)。结论:采用清胰汤与万古霉素用于治疗重症急性胰腺炎患者,可有效提高重症急性胰腺炎的治愈率,降低其继发感染率。
Objective: To evaluate the efficacy of vancomycin combined with Qingyitang in treating severe acute pancreatitis and its prevention and treatment of secondary infection. Methods: Fifty-six patients with severe acute pancreatitis who were diagnosed and treated between February 2011 and September 2013 were divided into observation group (n = 32) and control group (n = 24), and both groups were given liquid resuscitation , Gastrointestinal decompression, inhibition of pancreatic enzyme secretion, and correction of water and electrolyte, acid-base balance, anti-inflammatory, and the establishment of call, inhalation channel and purify the blood and other conventional treatment, observation group patients to gastric perfusion Qingyi Decoction and Vancomycin Superoxide dismutase treatment was compared between the two groups after treatment of clinical symptoms and signs of improvement and the occurrence of adverse reactions. Results: The effective rate and total effective rate in the observation group were 71.88% and 93.75%, respectively, which were significantly higher than those in the control group (41.67% and 79.17%, respectively). The difference between the two groups was statistically significant (P <0.05) The secondary infection rate of patients was 12.5%, significantly lower than that of the control group 37.5% (P <0.05). Conclusion: Qingyitang and vancomycin can be used to treat patients with severe acute pancreatitis, which can effectively improve the cure rate of severe acute pancreatitis and reduce its secondary infection rate.