论文部分内容阅读
目的为了解海南省健康人群中流行性流脑膜炎奈瑟菌(Nm)带菌状况及抗体水平,为制定流脑防治规划和预警提供科学依据。方法采用随机抽样方法抽取海口市、儋州市和东方市,以整群抽样法采集被抽中家庭全部人员健康人群咽拭子和静脉血,进行脑膜炎奈瑟菌(Nm)培养,用间接酶联免疫法监测血清标本中脑膜炎A、C群IgG抗体,含量≥2μg/ml为阳性。结果本次抽样检测744人,脑膜炎奈瑟菌(Nm)培养阳性9人,总带菌率为1.21%,A群和C群带菌都主要集中在儋州地区。共检测676人流脑IgG抗体,其中A群抗体阳性者420人,阳性率为62.13%。C群阳性者195人,阳性率为28.85%。不同年龄组抗体水平差异有非常显著性差异,35～45岁年龄组抗体水平最高(P<0.01);,A群流脑抗体阳性率62.13%显著高于C群流脑抗体28.25%,差异有统计学意义(P<0.01),C群抗体各地区间无差异。结论海南省健康人群中存在流脑奈瑟菌(Nm)带菌者,人群中流脑A、C群保护性抗体较低,应加强流脑的防控工作。
Objective To understand the epidemic status of Neisseria meningitidis (Nm) and antibody levels among healthy population in Hainan Province and provide a scientific basis for planning and early warning of prevention and control of. Methods A random sample was taken from Haikou City, Pizhou City and Dongfang City. Throat swabs and venous blood from all the healthy people in the family were collected by cluster sampling method. Neisseria meningitides (Nm) Enzyme linked immunosorbent assay serum samples meningitis A, C group IgG antibody, the content ≥ 2μg / ml is positive. Results A total of 744 samples were tested and 9 were positive for Neisseria meningitidis (Nm), with a total carrier rate of 1.21%. Cluster A and C were mainly found in Danzhou area. A total of 676 human IgG were detected, of which 420 were group A antibody positive, with a positive rate of 62.13%. 195 positive for C group, the positive rate was 28.85%. There were significant differences in antibody levels between different age groups, with the highest antibody level in 35-45 age group (P <0.01), the positive rate of meningococcal antibody in group A was 62.13%, significantly higher than that in group C meningococcal antibody 28.25% Statistical significance (P <0.01), C group antibody no difference between regions. CONCLUSIONS: Among the healthy population in Hainan Province, there are Neisseria meningitidis (Nm) carriers. The protective antibodies against meningococcal A and C in the population are relatively low, and prevention and control of meningitis should be strengthened.